2017.4-               福州大学化学学院  研究员  国家级青年人才/闽江学者特聘教授

2015.7-2017.4      美国霍华德休斯研究所    研究专员

2011.11-2015.6    美国德州大学西南医学中心  博士后

2009.7-2011.10    中国科学院福建物质结构研究所  博士后

2006.9-2009.6      中国科学院上海药物研究所    药物设计学  博士

2003.9-2006.7      福建农林大学    生物化学与分子生物学    硕士

       1999.9-2003.7      福建农林大学  生物科学    本科

课题组综合化学生物学、X-ray晶体学、生物化学以及分子生物学等研究手段，目前主要从事细胞周期调控和DNA损伤修复的分子机制以及靶向药物研发，以第一作者或通讯作者在Nature, Nature Chemical Biology和Cell Chemical Biology等杂志上发表多篇研究论文。

国家自然科学基金面上项目(31971222,2020.1-2023.12)
       国家青年人才计划项目（ 2017年）
       福建省高层次人才引进项目（2018年） 
       福建省高校领军人才及后备人才项目 （2018年）

1.Lin H#, Zhang D#, Zuo K#, Yuan C, Li J*, Huang M*, Lin Z*. Structural basis of sequence-specific Holliday junction cleavage by MOC1. Nat Chem Biol. 2019 Dec;15(12):1241-1248.

2. Lee HS, Lin Z, Chae S, Yoo YS, Kim BG, Lee Y, Johnson JL, Kim YS, Cantley LC, Lee CW, Yu H*, Cho H*. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications, 2018, 9(1): 3848.

3.Zhonghui Lin, Xuelian Luo, Hongtao Yu. Structural basis of cohesin cleavage by separase. Nature. 2016, 532: 131-134.

4.Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L, Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell Mol Med.2016, 20(10):1851-60.

5.Zhonghui Lin^#, Luying Jia^#, Diana R. Tomchick, Xuelian Luo, Hongtao Yu.Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting. Structure. 2014, 22:1-12. ( ^#Contributed equally)

6.Fanglei Chen, Guiping Zhang, Zebin Hong, Zhonghui Lin, Min Lei, Mingdong Huang, Lihong Hu. Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1). Bioorg Med Chem Lett.2014, 24(10):2379-82.

7.Zhonghui Lin^#, Jan K. Jensen^#, Zebin Hong, Xiaoli Shi, Lihong Hu, Peter A. Andreasen, and Mingdong Huang. Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist. Chemistry & Biology. 2013, 20:253-61. ( ^#Contributed equally)

8.Zhou R, Lin ZH, Jiang CS, Gong JX, Chen LL, Guo YW, Shen X. Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation. Acta Pharmacol Sin. 2013, 34(10):1325-36.

9.Hong Ze-Bin;Lin Zhong-Hui;Gong Li-Hu;Huang Ming-Dong. Crystal structure of PAI-1 in complex with gallate. Chinese Journal of Structural Chemistry. 2013, 32(7):1005-1012.

10.Zhonghui Lin, Longguang Jiang, Cai Yuan, Jan K.Jensen, Xu Zhang, Zhipu Luo,

Barbara C. Furie, Bruce Furie, Peter A. Andreasen, Mingdong Huang. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J. Biol. Chem. 2011, 286: 7027-32.

      11.Jacky Chi Ki Ngo, Longguang Jiang, Zhonghui Lin, Cai Yuan, Zhuo Chen, Xu Zhang, Haiyang Yu, Jundong Wang, Lin Lin, Mingdong Huang. Structural basis for therapeutic intervention of uPA/uPAR system. Curr Drug Targets. 2011, 12:1729-43.

     12.Liu Q, Zhang Y, Lin Z, Shen H, Chen L, Hu L, Jiang H, Shen X. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010,120: 155-63.

    13.Zhonghui Lin, Yu Zhang, Yinan Zhang, Hong Shen, Lihong Hu, Hualiang Jiang, and Xu Shen. Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via multi-target mechanism. Biochemical Pharmacology. 2008, 76:1251-62.

美国德州大学西南医学中心药理系年度优秀博士后（2016年） 
       国际血栓与止血协会“第三世界科学家奖”（2011年）
       中国科学院“地奥奖学金” （2009年）
       中科院上海药物所研究生优秀论文二等奖（2009年）