The National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies (CPT) was originated from the Fujian Functional Materials Engineering Research Center, which was established in December 2001. The center was funded by the Science and Technology Commission of Fujian Province to establish the Fujian Photodynamic Therapy and Diagnosis Engineering Technology Research Center in May 2009. CPT was officially funded by the National Development and Reform Commission in September 2016, and passed the external review organized by the Fujian Development and Reform Commission in April 2017.
CPT has a total lab space of 2152 m2, and is equipped with state-of-the-art instruments and infrastructure including GMP-compliant production facilities (150 m2). There are over 60 scientific staffs currently working at CPT, including 20 permanent stuffs (one National Natural Science Fund for Distinguished Youth Scholar, one Changjiang Scholar, four “Thousand Talents Program” Distinguished Professors, and seven Minjiang Scholars) and over 40 doctoral and master students.
CPT is devoted to the top tier basic research and R&D to meet national urgent technological demands. Currently, there are mainly three research directions as follows: (1) Photodynamic therapy and diagnosis technology for antitumor and antimicrobial applications; (2) Structural and computational biology; (3) Nanomaterials and their applications in environmental protection. A major achievement of CPT is the development of a novel anti-cancer drug, named Photocynine. This is the first photodynamic drug developed in China and received approval by NMPA for its clinical Phase I trial. Photocynine has completed its clinical Phase I trial, and has entered Phase II trial.
CPT has published over 100 peer-reviewed research articles and dozens of patents. The center has attracted over 30 extramural research grants from the National Program for Science and Technology Development, National Key Technology Research and Development Program of China during the “12th Five-Year Plan”, National Natural Science Foundation of China, and Special Science and Technology Campaign of Fujian Province with a total budget of 50 million RMB.
生物药光动力治疗技术国家地方联合工程研究中心是国家发改委批准建设的创新药物与光动力技术研究平台。2001年，中心经福建省发改委批准建设福建省功能材料研究中心。2009年，依托本中心，经福建省科技厅批准成立福建省光动力治疗药物与诊疗工程技术研究中心。2016年，经国家发改委批复，列入国家地方联合共建计划。
中心现拥有实验室面积2152平米，中试车间150平米，先进的新药研发与光动力技术相关仪器设备。现有科研团队成员60余人，其中包括国家杰出青年基金获得者1人、长江学者1人、国家百千万工程人才1人、中组部千人计划人才4人、福建省闽江学者7人、福建省百人计划人才4人。
中心长期致力于创新药物的基础研究与产业化开发，现有的研究方向包括了：（1）光动力与成像诊疗技术在抗肿瘤和抗菌中的应用；（2）结构与计算生物学；（3）纳米材料及其应用。中心自主创制的“福大赛因”及其注射液为首个获得NMPA批准进入I期临床的化学1类光动力抗癌新药，该药物正在进行II期临床试验研究。中心承担了国家科技部攻关项目1项、“十二五”科技专项3项、国家自然科学基金16项、福建省科技厅重大项目6项、国际合作重点项目1项、福建省发改委产业化项目1项、及企业横向项目多项，获得省部级以上科技奖项6项。
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