图片标题1


教育工作经历

教育经历(按时间倒排序):
       1989/1 - 1993/3,美国俄勒冈州立大学,博士
       1982/9 - 1985/7,厦门大学,物理化学,硕士
       1978/9 - 1982/7,福州大学,物理化学,学士
 
      工作经历(科研与学术工作经历,按时间倒序排序):
      2016/05至今,  福州大学,化学学院,教授
      1999/09-2015/06,哈佛医学院贝思以色列研究中心结构生物学实验室,主任
      2003/07-2016.01,中科院福建物构所化学生物学研究室,研究室主任
      1993/03-1999/07,美国斯奎伯斯研究所,分子生物学系,博士后
      1985/09-1988/12,中科院福建物质结构研究生所,助理研究员

教学简介

在国外工作期间,培养博士后6名。回国后,在中科院福建物构所工作期间成功申报“生物化学和分子生物学”博士点(2005年)。培养硕博士研究生29名,已毕业博士13名,硕士8名。12名博士到国外进修博士后,其中四人已经回国在国内高校担任教授。4名硕士到国外继续深造博士学位。林忠辉博士在日本举行的ISTH国际会议上受邀会议报告,获得了《第三世界科学家奖》,全国仅有两人获此殊荣。多年来与国外单位开展研究生联合培养,中国丹麦联合培养硕博士,已有一人获得丹麦博士学位,一人获得了丹麦的Danida奖金,目前还有两人获得丹麦奖学金在攻读丹麦博士学位,同时开展中法博士联合培养,已毕业2人。

科研简介

学术上,发表原创科研文章150多篇,有五篇发表在《科学》和《自然》及子刊杂志上,其中三篇为第一或通讯作者。申请国家发明专利7项(已授权3项)。基础研究方面,开展两方面的工作:

(1)生物学结构功能研究,侧重于水解酶和其调控蛋白(尿激酶受体uPAR、内源性抑制剂PAI-1tPA)。测定了血栓和纤溶系统中的重要蛋白质的三维结构,包括一系列尿激酶受体和尿激酶复合物uPAR:uPA,   uPA:peptide, tPA:PAI-1uPA:PAI-1的晶体结构。并且研发了一系列的0抑制剂,如针对PAI-1uPA的抑制剂,发现了抑制剂研发的新原理;还开发了受体uPAR的抑制剂,把其中一个抑制剂ATF和人血清蛋白HSA融合以提高血浆半衰期和提供融合蛋白的药物载体性质。在白蛋白研究方面,获得了一个惊奇的结果:has白蛋白可以诱导葡萄糖结构从环状转换成线性,从而启发这个旧蛋白全新的功能。在国际学术杂志上发表了一系列的高水平研究论文和综述,在水解酶及其调控蛋白、受体蛋白领域,特别是尿激酶和尿激酶受体的结构和功能研究方面处于世界一流行列:获得了国家基金委重大国际合作和科技部863等国家级项目的资助,也获得国外机构如澳大利亚国家健康与医学研究理事会(NHMRC)的资助,此外,还获得了制药公司的资助,包括了美国辉瑞制药、中科院诺和诺德中心和浙江海正制药。

(2) 基于光动力学的肿瘤靶向治疗、抗感染、以及荧光检测研究

发展了单一羧基取代的酞菁锌(CPZ)的大量合成和纯化(Chen et al.,Inorg Chem Commun 2006;9:313),这项专利技术使得有可能把酞菁锌和多肽或蛋白通过化学偶联中一起、制备靶向性的光敏剂,使用该技术开展了系列主动靶向光敏剂的抗肿瘤研究,例如,通过尿激酶受体抑制剂(如ATF)靶向的光敏剂(如Chen   et al.,Acta Biomater.2014,10:4257-68);通过促性腺激素释放激素靶向乳腺癌并避免血脑屏障通透性的光敏剂(Xu,et al.,PLOS One,2012;7:e37051);靶向肿瘤表面负电荷的光敏剂(Chen et al.,ChemMedChem.2010;5:890)、以及表面电荷对靶向性的影响(Li et al.,Bioconjug Chem.2012;23:2168)。

与传统抗感染药物相比,光动力在抗感染有其独特的优点,如(1)抗菌谱广,可用于细菌、真菌、病毒、原虫等,对耐药菌株也同样有效;(2)该方法产生的细胞活性物质的扩散距离很短,在< 100埃之内就被灭活,因此能避免对毗连的宿主组织的损害;(3)可通过多种给药方式使光敏剂到达感染处,且多次治疗后病原微生物不会产生对光动力治疗产生耐受性等。我们在光动力抗感染领域也开展了系列研究工作、发展了靶向性广谱抗菌光敏剂ZnPc(Lys),取得了显著的成果:Chen JC,et al.J Porphyr   Phthalocya 2011,15:293-9;Chen Z, et al.   J.Lumin.2014,152:103-107;Chen Z,et al.J Biomed Opt   2016,21,018001。该项技术已经转让给青岛阳光动力共同开发基于此技术的产品,其中数种产品已经进入销售。

单羧基酞菁锌的纳米技术也用于纳米光敏剂的研究(Wang et al.,   Nanoscale.2014,6:8274;Li et al.,Theranostics 2014,4:642)。我们也将纳米技术用于探针荧光免疫分析与光动力治疗,发展了一种新技术(Lu S,et al. Angew Chem Int Edit 2015,54:7915-9;Zhou et al.,Angew Chem Int Edit. 2014,53:12498),优于目前常用的镧系解离增强荧光免疫分析技术(DELFIA),可以满足检测要求。

我们在系列酞菁光敏剂的合成和药学研究领域坚持了十多年的研究工作,发表了系列文章和综述(Li   et al., Chem. Commun., 2013;49:9570; Xue et al., Photodiagnosis Photodyn   Ther. 2011;8:267;Zafar et al.,  Curr Drug Metab 2015;16:816)。本中心黄金陵、陈耐生、薛金萍发展了一种国内自主研发的、唯一的一个1.1类光敏剂药物(“福大赛因”),并进入了临床二期实验,结果显示“福大赛因”体内毒性小、并有显著疗效!

社会兼职

《结构化学》杂志编委
  中国光学学会第二届生物医学光子学专业委员会常委
  中国生物医学工程学会生物医学光子学分会常委
  中国化学会应用化学学科卟啉-酞菁专业委员会委员
  福建省生物工程协会副主任

科研项目

1.国家重点研发计划“政府间国际科技创新合作”重点专项,“凝血和纤溶中的新机理和新疗法”,项目起止时间:2018-2020,项目编号:2017YFE0103200,经费:249万元,在研.

2. 澳大利亚国家健康与医学研究理事会(NHMRC), “Repurposing Amiloride into Breast   Cancer Drugs with a Dual-Targeting Mechanism”,项目起止时间:2016.01-2020.12,批准号:APP1100432,经费:65.1995万澳元,共同申请人,在研.
  3. 基金委面上项目,“GPI-LU亚家族蛋白的结构研究”,项目起止时间:2017.01-2020.12,经费:60万元, 申请人,在研.
  4. 基金委面上项目,“纤溶酶原激活物抑制因子及其新型抑制剂的结构研究”,项目起止时间:2014.01-2017.12,批准号:31370737,经费:80万元,在研
  5. 中科院-诺和诺德专项研究经费,项目起止时间:2012.01-2014.12,批准号:NNCAS-2012-5,经费:60万元
  6. 基金委面上项目,项目起止时间:2012.01-2015.12,批准号:21171167,经费:60万元
  7. 基金委重大国际合作,项目起止时间:2012.01-2014.12,批准号:31161130356,经费:250万元
  8. 美国国立卫生院,项目起止时间:2012.09-2017.04,批准号:U54 HL112302,经费:205万美元
  9. 中法蔡元培交流项目,项目起止时间:2011.05-2013.05,批准号:【2011】6019
  10. 福建省科技重点项目,项目起止时间:2010.3-2012.3,批准号:2010Y0057,经费:15万元
  11. 辉瑞公司横向合作项目,项目起止时间:2009.11-2011.12,经费:6.5万美元
  12. 浙江海正药业股份有限公司委托项目,项目起止时间:2008.12-2009.12,经费:15万元
  13. 苏州技术研究院委托项目,项目起止时间:2008.05-2009.12,经费:20万元
  14. 基金委重大国际合作,项目起止时间:2008.09-2011.8,批准号:30811130467,经费:100万元
  15. 美国国立卫生院,项目起止时间:2007.01-2011.12,批准号:R01 HL086584,经费:191.25万美元
  16. 美国国立卫生院,项目起止时间:2008.09-2014.05,批准号:P01 HL087203,经费:867.5万美元
  17. 基金委杰出青年,项目起止时间:2008.01-2010.12,批准号:30625011,经费:200万元
  18. 科技部863项目,项目起止时间:2007.01-2010.12,批准号:2006AA02A313,经费:495万元17.中科院创新基地重要方向项目,项目起止时间:2007.01-2010.12,批准号:C01050402,经费:100万元  
  19. 科技部973项目,项目起止时间:2007.01-2011.7,批准号:2007CB914304,经费:100万元
  20. 福建省发改委产业技术开发专项, 2006.01-2007.12,经费:20万元
  21. 基金委重点项目,项目起止时间:2005.01-2008.12,批准号:30430190,经费:135万元
  22. 中法先进研究计划,项目起止时间:2005.01-2006.12,经费:5万元
  23. 国家人事部高级人才,项目起止时间:2004.12-2005.12,批准号:41052,经费:30万元
  24. 结构化学国家重点实验室,项目起止时间:2004.01-2006.12,批准号:40073,经费:9万元
  25. 中科院百人计划,项目起止时间:2003.03-2006.02,批准号:IB021061,经费:200万元
  26. 福建省自然基金重点,项目起止时间:2003.11-2006.12,批准号:C0320003,经费:15万元
  27. 中科院物构所创新前沿交叉基金,项目起止时间:2003.10-2006.12,批准号:IP031049,经费:16万元
  28. 福建省青年创新基金,项目起止时间:2003.10-2006.12,批准号:2002J013,经费:6万元
  29. 美国心脏协会SDG项目,项目起止时间:2003.01-2006.12,批准号: 0330089N,经费:26万美元  
  30. 教育部回国人员启动经费,项目起止时间:2003.01-2004.12,经费:2.5万元

代表性论文

1.Huang M, Lu SF, Huang JQ and Huang JL (1987). Synthesis and   crystal structure of Mo3(3µ-O)(µ-S)3[S2P(OEt)2]4(C3H3N). J. Struc. Chem.   6:29.  
  2. Huang M, Chen YZ, Tian ZW  (1987). The Surface Enhanced Raman   Scattering (SERS) effect of Ag(delta+) complex on Ag electrode surface. Acta   Physico-Chimica Sinica 3:178.  
  3. Huang JQ, Lu SF, Shang MY, Lin XT, Huang M, Lin YH, Wu DM, Zhuang HH,   Huang JL, Lu JX (1987). Reactivity of the trinuclear Mo-S cluster   Mo3S4[S2P(OEt)2]4(H2O) and an interesting "pseudo-aromaticity" of   the Mo3(µ-S)3 structural unit. J. Struc. Chem. 6:219.  
  4. Huang M, Lu SF, Huang JQ, Huang JL (1988). Research on the substitution reaction   of the ligands in Mo3S4(dtp)4(H2O) ---Synthesis and crystal structure of   Mo3S4(
η-dtp)( η?-dtp)2(µ-dtp)(bpy).  Acta Physico-Chimica Sinica 4:611.    
  5. Huang JL, Huang JQ, Shang MY, Zhuang HH, Lu SF, Lin XT, Lin YH, Huang M,   Lu JX (1988). Structure and reactivity of molybdenum clusters with loose   coordination site, Mo3S4[S2P(OEt)2]4L. Pure & Appl. Chem. 60:1185.  
  6. Lu SF, Huang JQ, Huang M, Huang JL (1989). The reactivities of Mo clusters   - A selective substitution reaction of the bridging (dtp) ligand and the   crystal structure of Mo3S4(µ-O2CR)(dtp)3(py). Acta Chimica Sinica English   Edition 1:24
  7. Lu SF, Huang M, Huang JQ, Huang JL, Lu JX (1989). Substitution reaction of   ligands in trinuclear Mo clusters with "loose coordination site" as   well as synthesis and crystal structure of   [Mo3S4(dtp)3(C3H3N2)3](dtp).(CH3)2CO. Scientia Sinica B32:139.
  8. Huang M, Lu SF, Huang JQ, and Huang JL (1989). The replacement reaction of   trinuclear molybdenum cluster --- Syntheses and crystal structures of two   molybdenum clusters [Mo3S4(dtc)4(DMF)](EtOH) and [Mo3S4(dtc)4(py)](py)2(H2O).   Acta Chimica Sinica 47:121.  
  9. Lu SF, Huang M, Huang JQ, Huang ZX, Huang JL (1990). Structure of   Tris(diethyldithiophosphato-S,S')--(diethylthiophosphate-O,S)-mu(Oxazole)-3-sulfido-tri-2-sulfido-cyclo-trimolybdenum   (3 Mo-Mo). Acta Cryst. C46:2036.  
  10. Huang M, DeKock CW (1993). Triphenylsiloxy Complexes. A Novel Compound   Containing a Mo(VI)-P bond: MoO2(OSiPh3)2(PPh3). Inorg. Chem. 32:4.  
  11. Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson   IA, Balch WE (1996). Structure and mutational analysis of Rab   GDP-dissociation inhibitor. Nature 381:42.
  12. Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA   (1998). Structural basis of plasticity in T cell receptor recognition of a   self peptide-MHC antigen. Science 279:1166.
  13. Huang M, Syed R, Stura EA, Stone MJ, Stefanko RS, Ruf W, Edgington TS,   Wilson IA (1998). The Mechanism of an Inhibitory Antibody on TF-initiated   Blood Coagulation Revealed by the Crystal Structures of Human Tissue Factor,   Fab 5G9 and TF-5G9 Complex. J. Mol. Biol. 275:873.
  14. Rudd PM, Wormald, MR, Stanfield RL, Huang M, Mattsson N, Speir JA,   DeGennaro JA, Fetrow, JS, Dwek RA, Wilson RA (1999). Roles for Glycosylation   of Cell Surface Receptors Involved in Cellular Immune Recognition J. Mol.   Biol. 293:351.
  15. Shliom O, Huang M, Sachais B, Kuo A, Weisel CN, Nassar T, Bdeir K, Hiss   E, Gawlak S, Harris S, Mazar A, Higazi AA (2000). Novel Interactions between   Urokinase and Its Receptor, J. Biol. Chem. 275:24304.
  16. Huang M, Huang GQ, Furie B, Furie BC, Seaton B (2000). Molecular basis of   vitamin K-dependent protein-membrane interaction: Xray structure of   prothrombin-phospholipid complex at 2.0 angstrom. Blood 96(11):1928.
  17. Huang M, Ruf W, Edgington TS, Wilson IA (2000). Crystal Structure of a   TF-VIIa Complex – Conformation of a Mobile Loop.   FASEB J. 14:LB152.
  18. Rudolph MG, Huang M, Teyton L, Wilson IA (2001). Crystal Structure of an   Isolated Vα Domain of the 2C T-cell Receptor, J. Mol.   Biol. 314:1.
  19. Huang M, Weissman, JT, Wang C, Chen W, Wilson IA, Balch WE (2001).   Crystal Structure of Sar1-GDP at 1.7Å Resolution and the Role of the   N-terminus in ER Export. J. Cell Biology, 155(6):937.
  20. Huang M, Weissman JT, Wang C, Balch WE, Wilson IA (2002). Protein   engineering for crystallization of the GTPase Sar1 that regulates ER vesicle   budding. Acta Cryst. D58:700.
  21. Luz JG, Huang M, Garcia KC, Rudolph NG, Teyton L, and Wilson IA (2002).   Structural comparison of allogeneic and syngeneic TCR-pMHC complexes: a   buried alloreactive mutation subtly alters peptide presentation substantially   increasing Vβ interaction. J. Exp. Med,   195(9):1175-1186.
  22. Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B &   Furie BC (2003). Structural basis of membrane binding by Gla domains of   vitamin K–dependent proteins. Nature Structural   Biology, 10(9):751-6.
  23. Huang M, Furie BC and Furie B (2004). Crystal Structure of the   Calcium-stabilized Human Factor IX Gla domain bound to a   conformation-specific anti-factor IX antibody. J. Biol. Chem.,   279(4):14338-14346.
  24. Huang M Mazar AP, Parry G, Higazi AA, Kuo A, Cines DB (2005).   Crystallization of soluble urokinase receptor (suPAR) in complex with   urokinase amino-terminal fragment (1-143). Acta Crystallogr D. 61(6):697-700.    
  25. Shi X, Li Y, Bian C, Zhao G, Huang M (2005) Crystallization of an   anti-factor IX antibody and its complex. Acta Crystallogr D. 61:701-3.
  26. Yuan C, Liu S, Huang M (2005) Application of Molecular Biology in Protein   Crystallization, Prog. Biophy Biochim, 32(2) 111-114.
  27. Bian C, Yuan C, Lin L, Lin J, Shi X, Ye X, Huang Z, Huang M (2005).   Purification and preliminary crystallographic analysis of a Penicillium   expansum lipase, BBA - Protein and Proteomics, 1752:99-102.
  28. Bian C, Yuan C, Zhao G, Li Y, Huang M (2005). Progress in the structural   study of urokinase receptor system, China Biotech. 25:144-147.
  29. Li Y, Parry G, Chen L, Callahan JA, Mazar AP and Huang M (2005).   Optimization of crystals of an inhibitory antibody of urokinase plasminogen   activator receptor (uPAR) with hydrogen peroxide and low protein   concentration, Prot Pep Lett, 12(7):655-658.
  30. Zheng Y, Yan F, Huang M (2006). Progress in the study of photodynamic   antimicrobial control of oral infection. Oral Medicine, 2006, 33, 68-71. 郑瑜谦   闫福华 黄明东(2006) 光动力治疗口腔细菌性感染的研究进展,《外国医学口腔医学分册》 2006, 33, 68-71 增刊
  31. Zheng Y, Yan F, Chen J, Zhao X, Li Y, Yuan C, Shi X, Huang M (2006). In   vitro antimicrobial study of a new photosensitizer on oral bacteria. J Oral   Science Research, 2006, 22(4):368-371. 郑瑜谦 闫福华 陈锦灿 赵欣 李永东 袁彩 石晓莉 黄明东(2006) 一种新型光敏剂对牙周致病菌的体外抗菌研究,《口腔医学研究》 2006, 22(4):368-371.
  32. Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li L, Yuan C,   Bian C, Chen C, Furie B, Furie BC, Cines DB, Huang M* (2006). Structure of   Human Urokinase Plasminogen Activator in Complex with its Receptor, Science,   311(5761):656-9.
  33. Zhao G, Yuan C, Bian C, Jiang L, Ye X, Huang Z, Huang M* (2006).   Expression, Purification, and Crystallization of Urokinase Catalytic domain   in Pichia pastoris, Prog. Biophy Biochim, 33(4):1-5.
  34. Yuan C, Huai C, Bian C, Huang M* (2006). Expression, Purification and   Crystallization of Monomeric Soluble Human Urokinase Receptor, Prog. Biophy   Biochim, 33(3):1-5.
  35. Zhao G, Yuan C, Bian C, Hou X, Shi X, Ye X, Huang Z, Huang M* (2006).   Protein expression and preliminary crystallographic analysis of   amino-terminal fragment of urokinase-type plasminogen activator, Prot Exp   Purif, 49(1):71-7.
  36. Shi X, Zhu L, Zhang L, Yuan C, Chen J, Huang M* (2006). Functions and   Structure of Tumstatin: a Tumor Growth Suppressor, Tumor Studies, 33(5),   377-379.
  37. Rao Y, Yuan C, Bian C, Hou X, Li Y, Zhao G, Ye X, Huang Z, Huang M*   (2006). The Crystal Structure of Sar1[H79G]-GDP Provides Insight into the   Coat-controlled GTP Hydrolysis in the Disassembly of COPII, Chinese J.   Struct. Chem., 25(7):854-60.
  38. Yuan C, Ye, X, Huang M* (2006). Expression and purification of the   receptor binding domain of the spike protein in SARS-coronavirus, Chinese Journal   of Zoonoses 2006, 22(12), 1108-1110
  39. Rao Y, Bian C, Yuan C, Li Y, Chen L, Ye X, Huang Z, Huang M* (2006). An   Open Conformation of Switch I of Sar1 GTPase revealed by crystal structure at   Low Mg2+. Biochem Biophys Res Comm, 348(3):908-915
  40. Chen J, Chen N, Huang J, Wang J, Huang M* (2006) Derivatizable   phthalocyanine with single carboxyl group: synthesis and purification, Inorg.   Chem. Commun., 9:313-315.
  41. Hou, X, Chen M, Xie JM, Ye X, Zhao G, Yang F, Chen L, Huang M* (2007).   Crystallization and Preliminary Crystallographic Studies of Luffaculin 1, a   Ribosome-inactivating Protein from the Seeds of Luffa Acutangula, Chinese J.   Struct. Chem. 25(9), 1035-8.
  42. Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M* (2007). Effect of Human   Serum Albumin on Drug Metabolism: Structural Evidence of Esterase Activity of   Human Serum Albumin, J. Structural Biology, Feb;157(2):348-355
  43. Li Y, Parry G, Chen L, Callahan JA, Shaw DE, Meehan EJ, Mazar AP, Huang   M* (2007). An anti-urokinase plasminogen activator receptor (uPAR) antibody:   crystal structure and binding epitope, J. Mol. Biol. 365(4):1117-29
  44. Yuan C and Huang M* (2007) . Does uPAR exist in a latent form? Cell. Mol.   Life Sci., 64(9):1033-7.
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  137. Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink   SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R. Parmodulins inhibit   thrombus formation without inducing endothelial injury caused by vorapaxar.    Blood. 2015 Mar 19;125(12):1976-85. doi: 10.1182/blood-2014-09-599910.   Epub 2015 Jan 13.PubMed PMID: 25587041; PubMed Central PMCID: PMC4366627.
  138. Chen Z, Zheng W, Huang P, Tu D, Zhou S, Huang M, Chen X.    Lanthanide-doped luminescent nano-bioprobes for the detection of tumor   markers.  Nanoscale. 2015 Mar 14;7(10):4274-90. doi: 10.1039/c4nr05697c.   PubMed PMID: 25532615.
  139. Chen Z, Zhang Y, Wang D, Li L, Zhou S, Huang JH, Chen J, Hu P, Huang M   (2016) Photodynamic antimicrobial chemotherapy using zinc phthalocyanine   derivatives in treatment of bacterial skin infection. J Biomed Opt. 2016 Jan   1;21(1):18001. doi:10.1117/1.JBO.21.1.018001. PubMed PMID: 26747478.
  140. Jiang L, Andersen LM, Andreasen PA, Chen L, Huang M. Insights into the   serine protease mechanism based on structural observations of the conversion   of a peptidyl serine protease inhibitor to a substrate. Biochim Biophys Acta.   2016 (2016) Mar;1860(3):599-606. doi: 10.1016/j.bbagen.2015.12.009. Epub 2015   Dec 12. PubMed  PMID: 26691138.
  140. Chen Z, Zhang Y, Wang D, Li L, Zhou S, Huang JH, Chen J, Hu P, Huang M   (2016) Photodynamic antimicrobial chemotherapy using zinc phthalocyanine   derivatives in treatment of bacterial skin infection. J Biomed Opt. 2016 Jan   1;21(1):18001. doi:10.1117/1.JBO.21.1.018001. PubMed PMID: 26747478.
  141. Jiang L, Andersen LM, Andreasen PA, Chen L, Huang M. Insights into the   serine protease mechanism based on structural observations of the conversion   of a peptidyl serine protease inhibitor to a substrate. Biochim Biophys Acta.   2016 (2016) Mar;1860(3):599-606. doi: 10.1016/j.bbagen.2015.12.009. Epub 2015   Dec 12. PubMed  PMID: 26691138.
  142. Ma H, Jiang L, Qiao S, Zhi Y, Chen XX, Yang Y, Huang X, Huang M, Li R,   Zhang GP. Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich   Domain (SRCR5) from Porcine CD163 Reveals an Important Residue Involved in   Porcine Reproductive and Respiratory Syndrome Virus Infection. J Virol. 2016   Nov 23. pii: JVI.01897-16. [Epub ahead of print] PubMed PMID: 27881657.
  143. Zhou X, Xu M, Huang H, Mazar A, Iqbal Z, Yuan C, Huang M. An ELISA   method detecting the active form of suPAR. Talanta. 2016 Nov 1;160:205-10.   doi:10.1016/j.talanta.2016.07.004. PubMed PMID: 27591605.
  144. Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A,   Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R. A substrate-driven   allosteric switch that enhances PDI catalytic activity. Nat Commun. 2016 Aug   30;7:12579. doi: 10.1038/ncomms12579. PubMed PMID: 27573496; PubMed Central   PMCID: PMC5013553.
  145. Jiang L, Lin L, Li R, Yuan C, Xu M, Huang JH, Huang M. Dimer   conformation of soluble PECAM-1, an endothelial marker. Int J Biochem Cell   Biol. 2016 Aug;77(PtA):102-8. doi: 10.1016/j.biocel.2016.06.001. PubMed PMID:   27270333.
  146. Yuan C, Jürgensen HJ, Engelholm LH, Li R, Liu M,   Jiang L, Luo Z, Behrendt N,Huang M. Crystal structures of the ligand-binding   region of uPARAP: effect of calcium ion binding. Biochem J. 2016 Aug   1;473(15):2359-68. doi:10.1042/BCJ20160276. PubMed PMID: 27247422.
  147. Kromann-Hansen T, Oldenburg E, Yung KW, Ghassabeh GH, Muyldermans S,   Declerck PJ, Huang M, Andreasen PA, Ngo JC. A Camelid-derived Antibody   Fragment Targeting the Active Site of a Serine Protease Balances between   Inhibitor and Substrate Behavior. J Biol Chem. 2016 Jul 15;291(29):15156-68.   doi:10.1074/jbc.M116.732503. PubMed PMID: 27226628; PubMed Central PMCID:   PMC4946931.
  148. Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L,   Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. A specific plasminogen   activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell   Mol Med. 2016 Oct;20(10):1851-60. doi: 10.1111/jcmm.12875. PubMed PMID:   27197780; PubMed Central PMCID: PMC4876229.
  149. Gong L, Liu M, Zeng T, Shi X, Yuan C, Andreasen PA, Huang M. Structural   basis of specific inhibition of tissue-type plasminogen activator by   plasminogen activators inhibitor-1. Data Brief. 2016 Jan 6;6:550-5.   doi:10.1016/j.dib.2015.12.050. PubMed PMID: 26909366; PubMed Central PMCID:PMC4731420.  
  150. Rullo AF, Fitzgerald KJ, Muthusamy V, Liu M, Yuan C, Huang M, Kim M, Cho   AE, Spiegel DA. Re-engineering the Immune Response to Metastatic Cancer:   Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor. Angew   Chem Int Ed Engl. 2016 Mar 7;55(11):3642-6. doi: 10.1002/anie.201510866.   PubMed PMID:  26879524.

151.Xu P, Andreasen PA, Huang M. Structural Principles in the   Development of Cyclic Peptidic Enzyme Inhibitors. Int J Biol Sci. 2017 Sep   21;13(10):1222-1233.  doi: 10.7150/ijbs.21597.   eCollection 2017. Review. PubMed PMID: 29104489; PubMed  Central PMCID: PMC5666521.

152.Li R, Zheng K, Yuan C, Chen Z, Huang M. Be Active or Not:   the Relative Contribution of Active and Passive Tumor Targeting of   Nanomaterials. Nanotheranostics. 2017 Jul 11;1(4):346-357. doi:   10.7150/ntno.19380. eCollection 2017. Review. PubMed PMID: 29071198; PubMed   Central PMCID: PMC5646738.

153.Xu P, Jia Y, Yang Y, Chen J, Hu P, Chen Z, Huang M.   Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone   Receptors. J Med Chem. 2017 Oct 26;60(20):8667-8672. doi:   10.1021/acs.jmedchem.7b01216. Epub 2017 Oct 10. PubMed  PMID: 28968084.

154.Chen S, Lin L, Yuan C, Gårdsvoll H, Kriegbaum MC, Ploug   M, Huang M. Expression and crystallographic studies of the D1D2 domains of   C4.4A, a homologous protein to the urokinase receptor. Acta Crystallogr F   Struct Biol Commun. 2017 Aug 1;73(Pt 8):486-490.   doi:0.1107/S2053230X17009748. Epub 2017 Jul 27. PubMed PMID: 28777093.

155.Rodnick KJ, Holman RW, Ropski PS, Huang M, Swislocki ALM.   A  perspective on Reagent Divesity and   Non-covalent Binding of Reactive Carbonyl Species (RCS) and Effector Reagents   in Non-enzymatic Glycation (NEG): Mechanistic Considerations and Implications   for Future Research. Front Chem. 2017 Jun 30;5:39. doi:   10.3389/fchem.2017.00039. eCollection 2017. PubMed PMID: 28713809; PubMed   Central PMCID: PMC5491550.

156.Xue G, Gong L, Yuan C, Xu M, Wang X, Jiang L, Huang M. A   structural mechanism of flavonoids in inhibiting serine proteases. Food   Funct. 2017 Jul 19;8(7):2437-2443. doi: 10.1039/c6fo01825d. PubMed PMID:   28644504.

157.Kromann-Hansen T, Louise Lange E, Peter Sørensen H,   Hassanzadeh-Ghassabeh G, Huang M, Jensen JK, Muyldermans S, Declerck PJ,   Komives EA, Andreasen PA. Discovery of a novel conformational equilibrium in   urokinase-type plasminogen activator. Sci Rep. 2017 Jun 13;7(1):3385. doi:   10.1038/s41598-017-03457-7. PubMed PMID: 28611361; PubMed Central PMCID:   PMC5469797.

158.Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z,   Yao L, Furie B, Huang M. A long-acting PAI-1 inhibitor reduces thrombus   formation. Thromb Haemost. 2017 Jun 28;117(7):1338-1347. doi:   10.1160/TH16-11-0891. Epub 2017 Apr 13. PubMed PMID: 28405670.

159.Liu M, Yuan C, Jensen JK, Zhao B, Jiang Y, Jiang L, Huang   M. The crystal structure of a multidomain protease inhibitor (HAI-1) reveals   the mechanism of its auto-inhibition. J Biol Chem. 2017 May   19;292(20):8412-8423. doi: 10.1074/jbc.M117.779256. Epub 2017 Mar 27. Erratum   in: J Biol Chem. 2017 Jun 23;292(25):10744. PubMed PMID: 28348076; PubMed   Central PMCID: PMC5437246.

160.Zhang Y, Zheng K, Chen Z, Chen J, Hu P, Cai L, Iqbal Z,   Huang M. Rapid killing of bacteria by a new type of photosensitizer. Appl   Microbiol Biotechnol. 2017 Jun;101(11):4691-4700. doi: 10.1007/s00253-017-8133-8.   Epub 2017 Mar 1. PubMed PMID: 28251266.

161.Liu D, Xu D, Liu M, Knabe WE, Yuan C, Zhou D, Huang M,   Meroueh SO. Small Molecules Engage Hot Spots through Cooperative Binding To   Inhibit a Tight Protein-Protein Interaction. Biochemistry. 2017 Mar 28;56(12):1768-1784.   doi:10.1021/acs.biochem.6b01039. Epub 2017 Mar 17. PubMed PMID: 28186725.

162.Liu M, Yuan C, Jiang Y, Jiang L, Huang M. Recombinant   hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2   cells, purification and crystallization. Acta Crystallogr F Struct Biol   Commun. 2017 Jan 1;73(Pt 1):45-50. doi: 10.1107/S2053230X16020082. Epub 2017   Jan 1. PubMed PMID: 28045393.

163.Ma H, Jiang L, Qiao S, Zhi Y, Chen XX, Yang Y, Huang X,   Huang M, Li R, Zhang GP. The Crystal Structure of the Fifth Scavenger   Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue   Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection. J   Virol. 2017 Jan 18;91(3). pii: e01897-16. doi: 10.1128/JVI.01897-16. Print   2017 Feb 1. PubMed PMID: 27881657; PubMed Central PMCID: PMC5244331.

获奖情况

中科院“百人计划”(2003年)
       国家“杰出青年科学基金”获得者(2006年)
       国家级百千万人才(2007年)
       国务院政府特殊津贴(2013年)
       福建省科技创新领军人才(2016年)

其他

国际合作方面,组建了中国丹麦第一个双边研究中心《中国丹麦肿瘤和水解酶联合研究中心》(2008年-2014年),丹麦方的合作单位是奥尔胡斯大学和哥本哈根大学等六个课题组。该项目通过了国际评估于2008年开始建设。该项目利用中丹双方科研力量的优势互补,共同开展针对肿瘤转移的检测和治疗的前沿性的基础攻关研究,研究成果发表到《Nature》等国际刊物上,特别是研发出针对肿瘤转移相关蛋白水解酶系统靶向性的诊断试剂,目前正在开展人体肿瘤的检测的临床实验。此外,获得中法先进研究项目、中法蔡元培基金、澳大利亚国家健康与医学研究理事会(NHMRC)的资助,共同开展研究工作和研究生联合培养。组织了多次国际会议,包括了2009年和2012年的中丹肿瘤和水解酶国际会议,以及2013年诺和诺德-中科院国际研讨会。应邀在多个国际会议上做大会邀请报告,包括了2006年第48届美国血液学年会、2006年第18届ISFP会议、2007年第21届ISTH(国际血栓和纤溶大会)、2007年International Workshop of Plasminogen Activation国际会议、2006-2016年的Gordon Research Conference on   Plasminogen Activation。